Biopharmaceutics and Biologic Drugs

Diabetes mellitus is a metabolic disorder, is becoming a serious threat to mankind health. Among all types of diabetes, type

2 diabetes is main complication which can be controlled with diet, exercise and oral medications. Oral medications are not insulin pills, rather four classes of drugs designed to improve the body’s utilization of what insulin is still present. These are sulfonylurea, metformin, troglitazone and acarbose but these oral medications will not be eff ective when islets of pancreas stop

making suffi cient insulin. So we have come with a dietary supplement which can be used as a soup for management of diabetes.

Th e composition of the supplement includes all dietary ingredients such as wheat fl our commonly known as bread wheat, barley powder, guar gum it’s a polysaccharide of galactose and mannose, which is water soluble polymer, exhibits a viscosifying

eff ect in water, onion powder commonly known as bulb onion, which contains quercetin, allicin, allinin and salt as required and turmeric powder that are harmless when given to patients. Our preliminary in vitro studies suggested good activity in modifying glucose absorption from the gut and we also carried out a prospective observational pilot study, to study the eff ect of dietary supplement on glycemic control in pre-diabetes (PD) and mildly uncontrolled diabetics (MUCD) and the results have shown that the dietary supplementation could be an adjuvant therapy which is safe, healthy and economic alternative for DM patients to control blood glucose levels and also that can minimize even the dose of OHAs.