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Anupam Bishayee

Anupam Bishayee

Larkin University, USA

Title: Natural product-based cancer prevention and intervention: From ethnopharmacology to modern medicine

Biography

Anupam Bishayee, Professor and Founding Chair, Department of Pharmaceutical Sciences, Larkin University College of Pharmacy presented an invited lecture titled
“Current affairs: black currants in health and disease” during 4th International Phytocosmetics and Phytotherapy Congress held in the ancient city of Antigua, Guatemala
during June 4-8, 2016. Dr. Bishayee also joined a panel of international experts on natural products during a roundtable discussion “Advances in Phytotherapy and
Ethnopharmacology” which identified support mechanisms that various scientific, academic and governmental agencies should provide to raise awareness about herbal
medicines and their use in the prevention and treatment of various diseases, including cancer.

Abstract

Natural products represent an important source for discovery and development of drugs for cancer prevention and therapy.
About 80% of all drugs approved by the United States Food and Drug Administration during the last three decades
for cancer therapy are either natural products per se or are based on, or mimicked natural products. Local and traditional
knowledge on natural resources has been instrumental for discovery and development of numerous successful drugs. To lead
the search for medicinal plants with potential anticancer activities, ethnopharmacological knowledge can provide a valuable
direction. Various extracts, fractions, mixtures and pure compounds from traditionally used plants have been found to
possess encouraging cytotoxic activities against numerous cancer cell lines. These agents have also been studied for cancer
preventive and therapeutic properties using preclinical animal models that mimic human cancers. The cancer preventive
and anticancer pharmacological attributes of various natural products and compounds can be explained by multiple cellular
and molecular mechanisms, including scavenging of free radicals, detoxification of free radicals, DNA repair, alteration of
cell cycles, programmed cell death (apoptosis), immune surveillance, anti-inflammatory, anti-angiogenic, anti-invasive and
antimetastatic activities as well as their ability to modulate a plethora of dysregulated oncogenic signaling molecules and
pathways. This presentation aims to present studies on cancer preventive and therapeutic attributes of various ethnobotanical
species and underlying mechanisms of action, including those reported from our own laboratory. Current limitations and
future directions of research for successful cancer drug development based on ethnobotany and ethnopharmacology will also
be discussed.