Jun Xu
Sun Yat-Sen University
Biography
Jun Xu, a professor of Medicinal and Computational Chemistry at Sun-Yat-Sen University (SYSU), has completed his PhD from University of Science & Technology of China and postdoctoral studies from Australian National University and McGill University. He is the founding Director of SYSU Research Center for Drug Discovery (RCDD), which consisits of Bio/Chemo-informatics lab, Drug Design lab, Phyto/Medicinal Chemistry lab, Structure biology lab, and Drug Screening lab. He is also the adjunct Professor of University of Pittsberg (Pittsberg, USA) and RMIT Univeristy (Melbourne, Australia). He has published more than a hundred papers in peer-reviewed and reputed journals, and served as an editorial board member of a number of reputed international journals.
Prof. Xu’s research involves in chemistry, pharmaceutical sciences, and informatics. Since the last century, I have been developing algorithms for chemoinformatics/ bioinformatics & pharmaceutical innovations, such as GMA (substructure/superstructure search, 1980s) CPA (fuzzy graph algorithm for protein structure determination from multi-dimensional NMR, 1990s), SCA (clustering large compound libraries, 2000s) and DLI algorithm (drug-like index, 2000s); WEGA (3D molecular superimposing, 2010s) DSGA (de novo frequent substructures recognition, 2010s). With these methods, his team discovered many drug leads against inflammation, virus, cancer and metabolic diseases. The lead compounds against nasopharyngeal carcinoma have entered the pre-clinic studies. He is the inventor of more than 20 patents. Website: www.rcdd.org.cn.
Abstract
Abstract : Finding Pharmaceutical Agents by Assembling Chemotypes