Bhabani Sankar Satapathy
NSHM College of Pharmaceutical Technology, India
Title: Lipid-based vesicular nanodrug carriers encapsulating a plant-derived anticancer agent showed successful blood-brain barrier permeation and retention in rats: A strategy for the effective treatment of glioma
Biography
Biography: Bhabani Sankar Satapathy
Abstract
Eff ective management of brain related ailments continues to be the challenging area in neuroscience research. Lipid based nanosize carriers owing to their structural uniqueness possess the ability to cross blood-brain barrier (BBB); the major hurdle for the successful transport of therapeutic agents into brain. Th e present study aimed for the development of a phospholipid based nanosize carrier encapsulating a plant derived therapeutic agent and investigation of its BBB crossing potential in vivo. Th e optimized formulation had a size range between 20-50 nm with smooth surface morphology. The formulation showed a narrow size distribution pattern with nearly 8% drug loading capacity. Cryo-transmission electron microscopy study revealed stable formation without any perforation on the outer surface. A sustained drug release profi le was observed for the experimental formulation up to 24 hours study period. Pharmacokinetic and biodistribution data showed an enhanced residence time of the experimental nanocarrier in brain as compared to the free drug. Gamma scintigraphy studies clearly evidenced an
efficient permeation of the nanocarriers through the BBB, as compared to the free drug. Further investigations are warranted to establish its future use in clinical practice.