Biopharmaceutics

Biography

Biography: Shobha Rani R Hiremath

Abstract

Skin is a significant barrier for the penetration of hydrophilic drugs. Generally, chemical permeation enhancers have been utilized in the dermal and transdermal systems to enhance the delivery of drugs. However, use of chemical permeation enhancers is associated with several disadvantages. Particularly, enhancers such as glycols, terpenes, surfactants, solvents such as alcohol and DMSO have been found to cause dermal irritation and more severe side effects on prolonged use. Therefore, there is huge demand for safer and economical methods of drug permeation enhancement across the skin. The existing biophysical technologies such as iontophoresis, sonophoresis, microneedles, electroporation and laser ablation methods are known to perturb the skin barrier which would take considerable amount of time to recover. Some of the technologies are not patient compliant either. A technology that enhances the delivery of drugs across the skin without affecting the skin structure and barrier properties is required in the present scenario. Magnetically mediated enhancement of drugs is a novel and simple approach to enhance the transdermal delivery of drugs. The magnetic field could be generated by placing simple permanent magnets on the drug reservoir or as a backing membrane in magnetic field. In this presentation, the use of magnetic field in the transdermal patch system and its efficacy as compared to chemical enhancers will be discussed.The development of patch system in addition to the data of in vitro permeation test and pharmacokinetic studies in human subjects will be presented.