Rubi Mahato
Fairleigh Dickinson University, USA
Title: Nanoemulsion as targeted drug delivery system for cancer therapeutics
Biography
Biography: Rubi Mahato
Abstract
Nanoemulsion serves as an attractive vehicle for the delivery of drugs, nucleic acids as well as imaging agents. Recently nanoemulsions have been extensively used for cancer diagnostics, imaging and therapy, especially due to their favorable properties to efficiently solubilize poorly aqueous soluble drugs, biocompatibility, high stability in vitro and in vivo, and their ability to accumulate in pathological areas with defective vasculatures. Since nanoemulsions are submicron emulsions with the droplet size falling in colloidal dispersion range, they impart the benefit of overcoming the anatomical and physiological barriers associated with drug delivery to the complex diseases such as cancer. Moreover, nanoemulsions can be engineered to carryout multiple functions by surface modification and encapsulation of pharmaceutical ingredients. Surface modification can be done by imparting the surface charge, attaching a targeting ligand, cell penetrating moieties, stimuli-sensitive groups and fluorescent dye, whereas the core can be loaded with drug, contrast agent and imaging agents. Such multifunctionality of nanoemulsion can be tailored to fit the requirement, hence smart nanoemulsions can be prepared.