Biopharmaceutics and Biologic Drugs

Drug Clearance

Drug Clearance can be defined as the plasma volume in the vascular compartment that is cleared of drug per unit of time. Total clearance gives an indication of drug elimination from the central compartment without reference to the mechanism of this process. For drugs that are eliminated by first-order kinetics, clearance is constant. Clearance by the kidneys is called renal clearance, and that by all other organs is referred to as nonrenal clearance. The latter most often represents clearance by the liver. Total clearance is the sum of all body clearances. The same factors that determine renal and hepatic elimination of drugs affect drug clearance.

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